Resumen

Introduction: This study was conducted to determine the prevalence of serotypes, virulence factors, and antimicrobial resistance patterns of Shigella spp. in Beijing, China, from 2004 to 2011. Methodology: Real-time PCR assays were used to detect virulent genes, and the Kirby-Bauer disk diffusion method was used to evaluate antimicrobial resistance. Results: Among the total of 1,652 Shigella isolates, S. sonnei (57.1%) was the predominant species, followed by S. flexneri (42.3%), S. dysenteriae (0.4%) and S. boydii (0.2%). Nineteen serotypes were discovered among S. flexneri strains. The virulence gene ipa H was the most frequent, followed by sen and set. The presence of set showed significant difference in two dominant serogroups, S. flexneri and S. sonnei. Over 90% of Shigella isolates showed resistance to at least three drugs with widened spectrum. High-level antimicrobial resistance to single and multiple antibiotics was more common among S. sonnei than S. flexneri. Conclusion: There was an obvious serotype change and a dramatic increase of antibiotic resistance in Shigella prevalence in Beijing.

Palabras clave: Shigella; serodiversity; prevalence; antimicrobial resistance; diarrhea.

2014-07-15   |   453 visitas   |   Evalua este artículo 0 valoraciones

Vol. 8 Núm.7. Julio 2014 Pags. 904-908 J Infect Developing Countries 2014; 8(7)