Resumen

Background: In this study, we tested the cross-reaction between crude Escherichia coli antigen (ECA) and 3 crude Schistosoma mansoni antigens. Methodology: The schistosomal antigens used were cercarial antigen preparation (CAP), soluble worm antigen preparation (SWAP), and soluble egg antigen (SEA). Four groups each of 3 mice received 2 intraperotineal immunizations with the above-mentioned antigens at a two-week interval. The dose of the ECA was 20 mg/100 mmmConclusion: It is necessary to include E. coli antigens as controls while establishing schistosomal antigens-based diagnostic tests to ensure the specificity of the detected immune responses. Characterization of the cross-reactive ECA antigens with protective potential against S. mansoni infection remains a future research objective.

Palabras clave: Escherichia coli Schistosoma mansoni T cells B cells epitope.

2009-05-13   |   1,614 visitas   |   Evalua este artículo 0 valoraciones

Vol. 3 Núm.3. Abril 2009 Pags. 206-217. J Infect Developing Countries 2009; 3(3)