Low-virulence phylogenetic background of CTX-M-producing Escherichia coli isolated from extraintestinal infections

Autores: Paiva Andyara L, Lincopan Nilton, Silva Ketrin C, Neves Patrícia R, Moreno Andrea M, McCulloch John A, Astolfi Ferreira Claudete S, Ferreira Antonio JP

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Background The Escherichia coli can play either a commensal or parasitic relationship with humans, with the latter leading to intestinal or extra-intestinal (EI) infections. Whereas commensal E. coli strains represent predominantly (low-virulence) phylogenetic groups A and B1, strains causing EI infections (which are known as ExPEC – Extraintestinal Pathogenic E. coli) have been shown to correlate to the high-virulence phylogroups B2 and D. However, E. coli strains exhibiting low-virulence backgrounds, such as the commensal strains, have been isolated under pathogenic conditions, indicating that pathogenic commensals can cause EI infections when the bacterium gains access to a normally sterile body site, mainly in patients with susceptibility linked to underlying disease.

Palabras clave: ExPEC; urinary tract infection; ESBL; CTX-M-1; CTX-M-2; CTX-M-15; ST648; Latin America.

2013-10-16   |   452 visitas   |   Evalua este artículo 0 valoraciones

Vol. 7 Núm.10. Octubre 2013 Pags. 756-760 J Infect Developing Countries 2013; 7(10)